5'-DNA:
A
T
G
C
G
C
T
A
A
T
G
C
T
G
A
C
C
T
A
G
A
T
C
G
>> [BIO-INGEST ⤏ HASH ⤏ PIPELINE] >>
A
1
C
0
G
1
T
0
A
1
T
0
C
1
G
0 >>
01001111 01001101 01001001 01000011 01010011 00101110 01000011 01001111
:BITS
5'-GENOME:
T
A
G
C
C
T
A
G
G
A
T
C
A
T
C
G
C
A
T
A
>> [BWA-ALIGN ⤏ GATK4 ⤏ ML-EMIT] >>
T
0
G
1
C
0
A
1
T
0
C
1 >>
01101111 01101101 01101001 01100011 01110011 00101110 01100011 01101111
:BITS
5'-DNA:
A
T
G
C
G
C
T
A
A
T
G
C
T
G
A
C
C
T
A
G
A
T
C
G
>> [BIO-INGEST ⤏ HASH ⤏ PIPELINE] >>
A
1
C
0
G
1
T
0
A
1
T
0
C
1
G
0 >>
01001111 01001101 01001001 01000011 01010011 00101110 01000011 01001111
:BITS
5'-GENOME:
T
A
G
C
C
T
A
G
G
A
T
C
A
T
C
G
C
A
T
A
>> [BWA-ALIGN ⤏ GATK4 ⤏ ML-EMIT] >>
T
0
G
1
C
0
A
1
T
0
C
1 >>
01101111 01101101 01101001 01100011 01110011 00101110 01100011 01101111
:BITS
3'-ANTISENSE:
C
G
A
T
T
A
C
G
C
A
T
A
A
G
T
C
A
G
C
T
>> [FASTQ-QC ⤏ K-MER ⤏ BITSTREAM] >>
G
1
A
0
T
1
C
0
G
1
A
0 >>
11010010 10011100 00110101 11001010 01010111 11100010 10101101 01000011
:BITS
3'-EXOME:
A
T
G
C
C
A
T
G
A
T
G
A
T
C
G
T
G
A
A
C
>> [TRANSCRIPT ⤏ QUANT ⤏ FP32] >>
C
1
T
0
A
1
G
0
C
1
T
0 >>
01010011 01000101 01010001 01010101 01000101 01001110 01000011 01000101
:BITS
3'-ANTISENSE:
C
G
A
T
T
A
C
G
C
A
A
A
A
G
T
C
A
G
C
T
>> [FASTQ-QC ⤏ K-MER ⤏ BITSTREAM] >>
G
1
A
0
T
1
C
0
G
1
A
0 >>
11010010 10011100 00110101 11001010 01010111 11100010 10101101 01000011
:BITS
3'-EXOME:
A
T
G
C
C
A
T
G
A
T
G
A
T
C
G
T
G
A
A
C
>> [TRANSCRIPT ⤏ QUANT ⤏ FP32] >>
C
1
T
0
A
1
G
0
C
1
T
0 >>
01010011 01000101 01010001 01010101 01000101 01001110 01000011 01000101
:BITS
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